Discover how to take control of your digestive comfort
Have you been experiencing gut distress?
Uncomfortable bloating. Embarrassing gas attacks. Diarrhea one day, constipation the next. Abdominal pain that makes it feel impossible to wear pants.
When your digestive health is off, it affects you in many other ways too… though that’s where you’ll probably feel it first. It can get in the way of complete digestion and nutrient absorption. It can send your immune system into a frenzy. And it can mess with almost every aspect of your mental, emotional, and physical health.
That’s why it’s so important to prioritize your digestive health, including your gut microbiome—the trillions of bacteria that populate your gut. The best way to do that? Digestive bitters AND probiotics! That’s right, BOTH are essential to complete, balanced, and lasting wellness.
What Are Digestive Bitters?
So you’ve probably heard of probiotics before, but what about digestive bitters?
Well, nature has given us a special group of plants rich in bitter chemicals called digestive bitters. Their strong taste signals every part of your digestive system to get ready for work. Digestive bitters have been prized since ancient times to soothe digestive woes quickly or avoid them entirely.[1] They were used to combat common issues like indigestion, abdominal discomfort, and bloating.
The bitter taste activates enzymes, acids, hormones, and proteins that are needed for complete digestion—breaking down fats and other macronutrients, encouraging digestive muscles to get moving and sending “I’m full” signals.[2]
Bitters work by triggering special T2R receptors all throughout the digestive system. For example, in the stomach, they simultaneously prompt digestive enzyme and acid production for complete food breakdown while promoting mucus production that protects the stomach lining. In the small intestines, T2R receptors signal the pancreas to release enzymes and the liver to release bile for more effective nutrient absorption.
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Bitters Deliver Big Benefits
Bitters help vastly improve almost every facet of digestion. When digestion is more effective and efficient, you get more benefit out of every bite you eat. You can count on bitters for:[3,4,5]
- Protection for mucosal barriers in the stomach and gut
- Smoother, more regular bowel movements
- Relief from occasional digestive issues such as gas, bloating, and heartburn
- Stronger “stop eating” signals so you’re less likely to overeat
- Increased nutrient absorption
- Enhanced GLP-1 production, the hormone that helps regulate blood sugar and metabolism
Optimal digestion shows up as overall wellness. With access to more nutrients, antioxidants, and other beneficial compounds, your body can more easily perform its daily functions that help you feel your best. That includes things like having plenty of energy, a more robust immune system, and better blood sugar and weight management.
What Are Probiotics?
Probiotics are beneficial bacteria (and sometimes yeasts) that contribute to overall health and wellness. We all have trillions of these bacteria on and in our bodies, with the vast majority making their home in the large intestine (where your gut microbiome resides). In a healthy gut, probiotic bacteria greatly outnumber harmful pathogens. Those probiotics keep pathogens under control to stop them from causing problems.
Gut imbalances occur when pathogenic populations begin to dominate in the microbiome. This causes dysbiosis, a condition where pathogens grow and multiply faster than probiotics. When the pathogens control the gut microbiome, they attack the mucosal gut barrier causing leaky gut. They produce all sorts of inflammatory compounds, and they prevent probiotic bacteria from creating beneficial compounds that support good health.
Dysbiosis can lead to digestive issues and even cause problems throughout the whole body including:
- Diarrhea
- Constipation
- Gas
- Bloating
- Abdominal discomfort
- Fatigue
- Food sensitivities
- Weight gain
- Immune system imbalances
This is why maintaining a balanced gut microbiome with a diverse population of probiotic bacteria can transform your well-being for the better, offering long-term, foundational benefits far beyond smooth, comfortable digestion.
Probiotics Play a Crucial Part
What happens in your gut microbiome affects your whole body[6,7] and has direct connections to your brain, liver, and immune system. It impacts kidney, heart, lung, and skin health.
Decades of scientific studies show that probiotic bacteria deliver substantial benefits for your overall health and wellness including:
- Total digestive comfort[8]
- Production of essential compounds including short chain fatty acids (SCFAs), nutrients like B vitamins, and antioxidants like lycopene[9,10,11]
- A strong protective mucosal gut barrier[12]
- Balanced immune system function[13]
- Proper inflammatory responses[13]
- Healthy weight maintenance[14]
- Restorative sleep[15]
All of this depends on a gut microbiome full of a wide variety of probiotic bacteria. The best way to achieve that? A high-quality probiotic supplement…

How Bitters and Probiotics Work Together for Gut Health
Both digestive bitters and probiotics support optimal digestive and gut health, but they do it in different ways.
Digestive bitters promote complete and efficient digestion by triggering the release of acids, enzymes, and hormones. And when those bitter substances reach the gut, they support probiotic gut bacteria and the mucosal gut barrier.
Here are just some of the digestive bitters that you can count on for the best digestive support:
- Wild Yam Root Extract. Wild yam helps promote healthy inflammatory responses in the digestive tract[16] and supports a balanced gut microbiome full of diverse probiotic bacteria.[17]
- Barberry Root. Barberry contains bitter compounds like berberine that impact the digestive system.[18] This bitter plant calms the smooth muscles in the intestines to increase digestive comfort and increase diversity in the gut microbiome for healthier balance.[19,20]
- Coptis Root Extract. Coptis root helps protect against leaky gut.[21] In traditional medicine, coptis root is commonly used to support digestive comfort and regular bowel movements.
- Dong Quai Root. This herb promotes healthy inflammatory responses and helps protect the mucosal gut barrier.[22]
- Dandelion Root. Bitter dandelion root keeps things moving in the digestive tract for increased comfort. It also acts as a prebiotic that nourishes beneficial bacteria in the gut microbiome and supports healthy inflammatory responses in the digestive tract.[23]
These digestive bitters work synergistically with probiotic supplements—particularly highly effective spore probiotics—for a healthy, balanced gut microbiome and optimal digestive health.
Unlike other probiotics, spore probiotics arrive in your gut 100% alive every time. That’s because their endospore shell protects them from stomach acids, digestive enzymes, and other perils as they move through your digestive system. And when they reach the gut, spore probiotics quickly begin to clear space for a wide variety of beneficial probiotic bacteria. Spore probiotics work to:
- promote regular stools[24]
- support a strong gut barrier[25]
- encourage increased beneficial bacterial diversity[26]
- discourage occasional indigestion, bloating, and heartburn[27]
Together, spore probiotics and digestive bitters support every facet of healthy, comfortable digestion in a complementary way.
When Do You Need Digestive Bitters vs. Probiotics?
While digestive bitters affect all of the digestive process, according Kiran Krishnan, the research microbiologist behind Just Thrive, their biggest impact is on the stomach and small intestine.
Bitters are especially key for proper gastric emptying. When food sits in the stomach for too long, it can cause digestive discomfort. That’s why digestive bitters provide fast-acting relief for occasional digestive troubles including bloat, nausea, indigestion, and that post-meal “stuck” feeling.
Spore probiotics, on the other hand, have the greatest impact on the large bowel and offer long-term support for your gut, microbial health and diversity, and overall wellness.
They are foundational to not only your gut health, but your immunity, energy, sleep, mental health, and more.
Should You Take Bitters and Probiotics Every Day?
Kiran says yes. But ultimately it's up to you and the extent of your digestive discomfort.
For the bitters, take 2 capsules 10-15 minutes before your largest meal (or with your meal) for best results. Plus, they promote natural GLP-1 activity helping you feel full and curbing cravings.
And because probiotics are the cornerstone of your health, Kiran recommends taking them on a regular basis for on-going optimal health. Take 1 capsule per day with your largest meal or as directed by your physician.
Welcome Optimal Gut Health and Comfort with Just Thrive
Imagine what it’s like when your gut feels comfortable all the time. When you can reap the biggest bounty of nutrients from everything you eat. When you just feel overall healthy and energetic.
With optimal production of digestive acids and enzymes… a gut microbiome full of diverse beneficial bacteria… a strong mucosal gut barrier… you’ll feel ready to take on anything. And Just Thrive Digestive Bitters and Just Thrive Probiotic together can help you get there.
Just Thrive Digestive Bitters is a carefully crafted formula that delivers 12 time-tested bitters including wild yam root, dandelion root, barberry root, coptis root, and dong quai root. Just Thrive Digestive Bitters was created to stimulate digestive activity and promote the production and release of digestive enzymes.
Even better, Just Thrive Digestive Bitters comes in a convenient, tasteless capsule that delivers all the digestive benefits without the bitter taste.
Just Thrive Probiotic delivers a combination of four clinically studied spore probiotics known to support a healthy, balanced gut microbiome full of a diverse population of beneficial bacteria. Just Thrive Probiotic contains:
- Bacillus subtilis HU58™
- Bacillus indicus HU36™
- Bacillus clausii
- Bacillus coagulans
>> Enjoy complete, smooth digestion with Just Thrive Digestive Bitters and Just Thrive Probiotic every day.
And if you’re not sure about trying Just Thrive Digestive Bitters and Just Thrive Probiotic, we can help with that.
EVERY Just Thrive purchase is covered by our Bottom of the Bottle, 100% money back guarantee.
So you can try Just Thrive Digestive Bitters and Just Thrive Probiotic to see if they work for you… and we’re confident that they will.
But if for any reason you don’t feel a difference, simply request a full product refund at any time. It doesn’t matter if it’s 3 months or even 3 years later. It doesn’t even matter if the bottle is empty! You’ll get your money back any time, no matter what.
>> Try Just Thrive Probiotic and Digestive Bitters RISK-FREE today, and save 30% on your first month’s subscription with code SUB30.

Sources
- McMullen MK, Whitehouse JM, Whitton PA, Towell A. Bitter tastants alter gastric-phase postprandial haemodynamics. J Ethnopharmacol. 2014 Jul 3;154(3):719-27.
- McMullen MK, Whitehouse JM, Towell A. Bitters: Time for a New Paradigm. Evid Based Complement Alternat Med. 2015;2015:670504.
- Aleman RS, Moncada M, Aryana KJ. Leaky Gut and the Ingredients That Help Treat It: A Review. Molecules. 2023 Jan 7;28(2):619.
- Rezaie P, Bitarafan V, Horowitz M, Feinle-Bisset C. Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans? Nutrients. 2021 Apr 16;13(4):1317.
- Xie C, Wang X, Young RL, Horowitz M, Rayner CK, Wu T. Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control. Front Endocrinol (Lausanne). 2018 Sep 27;9:576.
- Maftei NM, Raileanu CR, Balta AA, Ambrose L, Boev M, Marin DB, Lisa EL. The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties. Microorganisms. 2024 Jan 23;12(2):234.
- Bodke H, Jogdand S. Role of Probiotics in Human Health. Cureus. 2022 Nov 9;14(11):e31313.
- Iancu MA, Profir M, Roşu OA, Ionescu RF, Cretoiu SM, Gaspar BS. Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation. Microorganisms. 2023 Aug 29;11(9):2177.
- Fusco W, et al. Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota. Nutrients. 2023 May 6;15(9):2211.
- Uebanso T, Shimohata T, Mawatari K, Takahashi A. Functional Roles of B-Vitamins in the Gut and Gut Microbiome. Mol Nutr Food Res. 2020 Sep;64(18):e2000426.
- Sy C, Dangles O, Borel P, Caris-Veyrat C. Interactions between Carotenoids from Marine Bacteria and Other Micronutrients: Impact on Stability and Antioxidant Activity. Mar Drugs. 2015 Nov 19;13(11):7020-39.
- Takiishi T, Fenero CIM, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017 Oct 2;5(4):e1373208.
- Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R. Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front Immunol. 2021 Feb 26;12:578386.
- Noor J, Chaudhry A, Batool S, Noor R, Fatima G. Exploring the Impact of the Gut Microbiome on Obesity and Weight Loss: A Review Article. Cureus. 2023 Jun 25;15(6):e40948.
- Marotta A, Sarno E, Del Casale A, Pane M, Mogna L, Amoruso A, Felis GE, Fiorio M. Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality. Front Psychiatry. 2019 Mar 27;10:164.
- Huang CH, Pan CL, Tsai GJ, Chang CJ, Tsai WC, Lu SY. Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy. Molecules. 2021 Apr 23;26(9):2471.
- Li X, Li J, Ji J, Li S, Yao X, Fan H, Yao R. Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy. J Neurochem. 2024 Dec;168(12):3982-4000.
- Imenshahidi M, Hosseinzadeh H. Berberine and barberry (Berberis vulgaris): A clinical review. Phytother Res. 2019 Mar;33(3):504-523.
- Wolf PG, et al. Berberine alters gut microbial function through modulation of bile acids. BMC Microbiol. 2021 Jan 11;21(1):24.
- Chen C, Lu M, Pan Q, Fichna J, Zheng L, Wang K, Yu Z, Li Y, Li K, Song A, Liu Z, Song Z, Kreis M. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. PLoS One. 2015 Dec 23;10(12):e0145556.
- Yang Y, Vong CT, Zeng S, Gao C, Chen Z, Fu C, Wang S, Zou L, Wang A, Wang Y. Tracking evidences of Coptis chinensis for the treatment of inflammatory bowel disease from pharmacological, pharmacokinetic to clinical studies. J Ethnopharmacol. 2021 Mar 25;268:113573.
- Chen, Y, et al. The intestinal delivery systems of ferulic acid: Absorption, metabolism, influencing factors, and potential applications. Food Frontiers. Volume5, Issue3 May 2024 Pages 1126-1144.
- Li Y, Chen Y, Sun-Waterhouse D. The potential of dandelion in the fight against gastrointestinal diseases: A review. J Ethnopharmacol. 2022 Jul 15;293:115272.
- Catinean A, Neag AM, Nita A, Buzea M, Buzoianu AD. Bacillus spp. Spores-A Promising Treatment Option for Patients with Irritable Bowel Syndrome. Nutrients. 2019 Aug 21;11(9):1968.
- Rhayat L, Maresca M, Nicoletti C, Perrier J, Brinch KS, Christian S, Devillard E, Eckhardt E. Effect of Bacillus subtilis Strains on Intestinal Barrier Function and Inflammatory Response. Front Immunol. 2019 Mar 29;10:564.
- Marzorati M, Van den Abbeele P, Bubeck S, Bayne T, Krishnan K, Young A. Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system. Food Res Int. 2021 Nov;149:110676.
- Patch C, Pearce AJ, Cheng M, Boyapati R, Brenna JT. Bacillus Subtilis Improves Self-Reported Symptoms for Constipation, Indigestion, and Dyspepsia: A Phase 1/2A Randomized Controlled Trial. Nutrients. 2023 Oct 24;15(21):4490.